UROLITHIN A/ 1143-70-0 CAS NO.1143-70-0

We have two factories in Dezhou , Shandong and Xianning, Hubei. The factory covers an area of 48,000 square meters with the building area of 26,000 square meters. We are specialized in the manufacture of pharmaceutical intermediates and cosmetic additives with good inspection equipments and innovative R & D capability.

1. We manufacturer this product for more than10 years
2. We are the TOP5 enterprises in the industry
3. Our product quality is TOP3 in the industry
4. Our capacity is 15 - 20 tons per month
5. We pay more attention on delivery time, and usually ship on time.
6. We cooperate with many Korea , India , Europe customers, and enjoy good reputations.

Wuhan BJM Pharm Inc. established stable and reliable long-term cooperative relations with hundreds of domestic chemical factories. Through unremitting efforts, our products have exported to North America, Europe, Southeast Asia, etc., and have established long-term business relationship with customers all over the world.

Our company stick to the principle as: people-oriented, customer first, Hope to establish a win-win business relationship with all friends.

● Centralized customer service supports simplification of administrative procedures, resulting in time and cost saving.
● Our Chinese network and sophisticated logistics solutions ensure that chemicals of identical quality are supplied to customers with several manufacturing locations and contribute to security in planning and reliability of processes.
● Our processes are continuously optimized and adapted to our customers’ changing structures and requirements.

Description:

Urolithins are microflora human metabolites of dietary ellagic acid derivatives such as ellagitannins. They are produced in the human gut, and found in the urine in the form of urolithin B glucuronide after absorption of ellagitannins-containing food such as pomegranate,strawberries, red raspberries, walnuts or oak-aged red wine.
During intestinal metabolism by bacteria, ellagitannins and punicalagins are converted to urolithins, which have unknown biological activity in vivo in humans. Urolithins metabolites of pomegranate juice ellagitannins localize specifically in the prostate gland, colon, and intestinal tissues of mice.
Ellagitannins exhibit low bioavailability and are transformed in the gut to ellagic acid and its microbiota metabolites. Urolithins are found in plasma mostly as glucuronides at low concentrations.
Urolithins production is dependent on the gut microbiome enterotype. Individuals producing urolithins show a much higher abundance of the Clostridium leptum group of Firmicutes phylum than Bacteroides or Prevotella.
Urolithin M7 has also been synthetized from 2-hydroxy-4-methoxybenzaldehyde using the inverse electron-demand Diels–Alder reaction.

duct name	Urolithin A	Other name	6H-Dibenzo[b,d]pyran-6-one,3,8-dihydroxy-; 2',7-Dihydroxy-3,4-benzocoumarin; 2-Biphenylcarboxylicacid, 2',4,4'-trihydr
CAS	1143-70-0	Purity	Min 99%
MF:	C13H8O4	MW:	228.2
Structure
Usage	antioxidant; anti-inammatory; anticancer

In laboratory studies, urolithin A was shown to induce mitophagy, which is a selective recycling of mitochondria by autophagy, a process that cleans defective mitochondria following damage or stress, and tends to become less efficient during aging. This effect has been observed in different animal species (mammalian cells, rodents and C. elegans).